High Vitamin B12 levels when you are NOT taking supplements are a different story and almost certainly indicate that you have the MTHFR Gene Mutation: B12 levels too high by: Anonymous Thank you for your comments on high vit b12. (max is 900). They have had several blood tests done. American Academy of Dermatology. The most common diseases associated with high levels of the vitamin are kidney failure, blood cancers, leukemia, liver disease, polycythemia vera, and hypereosinophilic syndrome. Older adults with a vitamin B12 level less than 100 pg/mL (74 pmol/L) may also have symptoms. With alcoholic liver disease, vitamin B12 as well as its carrier proteins can be elevated. This makes it nearly impossible to overdose on the nutrient. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it in food. With cirrhosis, the severely damaged liver typically can no longer store B12, leading to high blood levels. An elevated vitamin B12 level can be a nonspecific indicator of several types of solid organ cancer. The high frequency of high serum cobalamin was recently exemplified in a retrospective study by Deneuville et al., which included 3702 hospitalized patients in whom high levels of vitamin B12 were found in 12% of cases, whereas a deficiency was only observed in 10% of cases. Photo courtesy of Shutterstock . Baltimore: Williams and Wilkins, 1999. There are a few different ways kidney disease is thought to contribute to high blood vitamin B12 levels. 2015;18(3):379-391. doi:10.1017/S1368980014000457, Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Vitamin B12 is considered to be very safe. Not surprisingly, a r … Agency for Healthcare Research and Quality. Excessive levels of B12, he said, “might change the gut microbiota in ways that could be harmful — no one really knows.”, Still, Dr. Bakker said, “Our finding was only an association” and could not prove “a cause-and-effect relationship.”. Which is very high. Vitamin B12 is generally not present in plant foods, but fortified breakfast cereals are a readily available source of vitamin B12 with high bioavailability for vegetarians [5,13-15]. Holick MF. The use of calcium and vitamin D in the management of osteoporosis. In the January 3 JAMA Network Open, scientists led by Jose Flores-Guerrero and Stephan Bakker, University of Groningen, the Netherlands, reported that people who have high levels of the vitamin in their blood are more likely to … High Vitamin B12 levels when you are NOT taking supplements are a different story and almost certainly indicate that you have the MTHFR Gene Mutation B12 levels too high Heaney, Robert P. “The Vitamin D Requirement in Health and Disease.” The Journal of Steroid Biochemistry & Molecular Biology 97 (2005):13-9. It is possible, based on certain conditions, that a vitamin B12 test may be inconclusive or incorrect, claims WebMD. Thank you. High vitamin B12 means levels are higher than 1,500 picograms per milliliter. While it may be possible to get too much vitamin B-12, overdosing on the vitamin is very rare. Leann Mikesh holds a Ph.D. in pathology. Vitamin D. In: Shils M, Olson J, Shike M, Ross AC, ed. Folate (>3.0 ng/mL) 14.3. Copyright © 2021 Leaf Group Ltd., all rights reserved. High vitamin B12 levels are associated with many blood diseases, including various types of leukemia and related blood disorders. Elevated blood levels of vitamin B12 are generally associated with increased amounts of proteins that carry vitamin B12 in the bloodstream or release of stored vitamin B12. Chronic myeloid leukemia is one such disease, in which the elevated vitamin B12 levels are thought to be due to release of excess B12 carrier proteins from the cancerous white blood cells. Vitamin B12 is not very tox ... Read More. Effectiveness and Safety of Vitamin D in Relation to Bone Health. Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. Taking certain medications, for instance, may affect the test results. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it in food. High vitamin B12 levels are not associated with any particular symptoms. 2007;85(6):1586-1591. doi:10.1093/ajcn/85.6.1586, Prentice RL, Pettinger MB, Jackson RD, et al. The American Journal of Clinical Nutrition. Vitamin B12 is a commonly used supplement and has been tested as a preventive treatment for Alzheimer’s disease, but could too much of it be bad for you? Public Health Nutr. Dizziness 2. Causes of High Blood Levels of Vitamin B12 Excess Vitamin Supplements. what causes extremely high serum vit b12 levels? Persons with low B12 levels were excluded together with persons with cancer … Deficiency should be confirmed by checking the level of a substance in the blood called methylmalonic acid. Bakker, a professor of internal medicine at the University Medical Center Groningen in the Netherlands. High B12 levels in the blood can be the result of liver disease, kidney failure and blood cancers. 2011;96(7):1-2. doi:10.1210/jcem.96.7.zeg33a, Sunyecz JA. This includes swelling of the face, tongue, and throat, and difficulty swallowing and breathing. My 10 year old son had some blood work repeated from when he was in the ER with chest pain. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. Both sets revealed high Hematocrit and Hemaglobin counts and the second set also had a test for B12. An increased blood level of vitamin B12 is sometimes caused by kidney disease, including diabetic kidney disease. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Arch Intern Med. When high doses of vitamin B 12 are given orally, only a small percentage can be absorbed, which may explain the low toxicity. High levels of homocysteine have an impact on the heart. 2013 Jun;32(3):375-81. doi: 10.1016/j.clnu.2012.08.014. “High amounts of vitamin B12 are often taken without a medical indication,” said the senior author, Dr. Stephan J.L. Levels of serum vitamin B12 may be raised in: If that is the case, then stop taking them and/or reduce the doses. There are no adverse affects from taking high doses vitamin B12. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Vitamin B12 is a water-soluble vitamin, which means that when we ingest too much of it, the excess amounts are flushed out of the body through urine. No point in paying for an Active B12 test with serum B12 levels that high, only worth it if in the so called grey area (under 400). Increased vitamin B12 levels are uncommon, because excess vitamin B12 is usually eliminated with urine. Chronic myeloid leukemia is one such disease, in which the elevated vitamin B12 levels are thought to be due to release of excess B12 carrier proteins from the cancerous white blood cells. 1 doctor answer. Headache 3. 2007 Mar;32(3):210-6. Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Giovannucci E, Liu Y, Hollis BW, Rimm EB. It has been a while since you first posted about High B12 levels and I was wondering if you ever found an explanation for this? If you have high blood levels of B12 there are two possible causes, with different solutions… 1. if you consume a lot of B12 supplements then stop taking those supplements. 2013;24(2):567-580. doi:10.1007/s00198-012-2224-2, Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. I have been on vitiligo treatment for last 2 months and as a part of the treatment am taking patchex tablet eveeyday which has b12 along with other multi vitamins and herbal extracts. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. A June 2013 review article published in the "Quarterly Journal of Medicine" reported that high vitamin B12 levels most commonly occur with liver cancer. Health Effects of High Levels. 2008; 168:1174-80. The liver is the main storage and clearance site for vitamin B12. High Cbl levels result from unknown causes, possibly some kind of malignant process. High vitamin B12 is a symptom of an underlying illness that causes the amount in your blood to increase. 2018;9:550. doi:10.3389/fendo.2018.00550, Ross AC, Manson JE, Abrams SA, et al. Vitamin B12, which is commonly found in a variety of foods, including fish, meat, eggs, and dairy products, is essential for maintaining the health of the body's nerve and blood cells — it also helps make DNA. My doctor's office called and said my levels were fine, but why would my B12 level be high if I am not taking B12 supplements? mine was 11,500! There is also a condition where a person has too many white blood cells … Answered by Dr. Thomas Namey: Nothing. Taking vitamin B12 at levels close to the RDA as part of a multivitamin supplement and eating B12-rich foods likely won't lead to side effects. Vitamin D (30-100.0 ng/mL) 36.8. It is important to carefully monitor how much vitamin B-12 you take to ensure that you do not take too much or too little. National Institutes of Health Office of Dietary Supplements. One of the main causes of increased vitamin B12 with liver disease is release of stored vitamin by liver cells that have died due to the disorder. Consuming large amounts of the vitamin won’t make you sick. An elevated vitamin B12 level can be a nonspecific indicator of several types of solid organ cancer. Vitamin D deficiency in minority populations. There is a low-cost blood test available that can detect this genetic defect. She has trained at the University of Virginia Medical Laboratories and has over 15 years experience in clinical, cancer and immunology research. The liver is the main storage and clearance site for vitamin B12. doi:10.1210/jc.2013-1195. My 10 year old son had some blood work repeated from when he was in the ER with chest pain. I thought this was really strange,” says Hope. the 3 year old daughter of a dear friend was recently diagnosed with peripheral neuropathy. Wilkins, Consuelo H. and Yvette I. Sheline, et al. Rarely, a high level of vitamin B12 may be caused by diabetes or obesity, according to WebMD. Vitamin B12 helps in improving energy levels. On top of that, we know that only a small percentage of vitamin B12 taken orally is actually absorbed. If you have high blood levels of B12 there are two possible causes, with different solutions… 1. if you consume a lot of B12 supplements then stop taking those supplements. Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine. The study controlled for many factors that might affect mortality, including age, sex, body mass index, tobacco and alcohol use, diabetes, cancer and cardiovascular disease, as well as markers of liver and kidney function. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it … Wait too long, and permanent neurological damage may occur. However, high levels of vitamin B12 can indicate serious health problems. Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. 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